When audiences meet Bruce Wayne he is a forensic pathologist, working in the bowels of Gotham Hospital and tasked with examining the victims of The Harvester, a gruesome serial killer preying on Gotham’s citizens. Not only will the superhero be forced to face his own mental demons, but he will also have to overcome them in order to save the citizens of Gotham as his alter-ego Batman.
- Winston Duke as Bruce Wayne / Batman, a forensic pathologist with Gotham Hospital.
- Jason Isaacs as Alfred Pennyworth, Batman's trusted butler
- Hasan Minhaj as The Riddler
- Gina Rodriguez as Barbara Gordon, the daughter of former police commissioner Jim Gordon and star detective for the Gotham police department
- Lance Reddick as Thomas Wayne, Batman's father
- Toks Olagundoye as Martha Wayne, Batman's mother
- John Rhys-Davies as Dr. Hunter
- Ashly Burch as Vicki Vale
- Sam Witwer as The Harvester, a serial killer preying on the citizens of Gotham. He is vicious and cannibalistic.
- Emmy Raver-Lampman as Kell, a sultry medical student helping Bruce Wayne while hiding a few secrets of his own.
- Jessica Marie Garcia as Renee Montoya
- Jim Pirri as Arnold Flass, a corrupt cop who uses his badge for his own personal gain.
- White, Peter (July 27, 2021). "Winston Duke & Jason Isaacs To Lead Spotify’s ‘Batman Unburied’ Podcast".
- Couch, Aaron (July 27, 2021). "‘Batman Unburied’: Winston Duke to Voice Star as Bruce Wayne (Exclusive)". Hollywood Reporter. Retrieved on March 8, 2022.