After spliting up with Joker Harley Quinn and three other female superheroes - Black Canary, Huntress and Renee Montoya - come together to save the lives of a little girl (Cassandra Cain) from an evil crime lord.
- Margot Robbie as Harleen Quinzel/Harley Quinn
- Jurnee Smollett-Bell as Dinah Laurel Lance/Black Canary
- Mary Elizabeth Winstead as Helena Bertinelli/Huntress
- Rosie Perez as Renee Montoya
- Ewan McGregor as Roman Sionis/Black Mask
To be added