Stephanie Lake was among the team of scientists working for Derek Powers, seeking a cure for his genetic mutation.
Stephanie Lake had just been recently hired to Wayne-Powers when she boldly interpolated Powers with a groundbreaking suggestion ― using his baseline DNA to build a new body, into which they would transfer his neuro-patterns. However, since Dr. Lake had never put that theory into practice, she decided to test it on someone who also had systemically damaged DNA. She then turned to Mr. Freeze, whose human remains were being kept in the laboratory. She convinced Freeze to undergo that procedure citing a renewed life in a new sane body.
The procedure appeared to be success at first. Indeed, Victor Fries was able to move about freely and go out into the world; interacting without the need for a containment suit. During this time, Dr. Lake started to show a romantic interest in him. Overtime however, Freeze's new body started to revert to its prior state, becoming intolerant to heat. Dr. Lake informed Powers that his body was reverting, and speculated that the cause was a pneumonic agent in his DNA. Powers observed that the only way to be certain was by biopsy Freeze's organs at that stage in order to confirm this and find a way around the problem. Dr. Lake took this on as a suggestion and as such she locked Mr. Freeze in room and raised its temperature, in an attempt to knock him unconscious. However, Freeze gathered enough strength to break his way out of the lab.
Right about when Dr. Lake was reassuring Derek Powers that Mr. Freeze wouldn't come back to settle the score, he laid siege on the building, donning a new containment suit. Surrounded, Dr. Lake begged Freeze to spare them, but when Powers tried to flee, he froze him anyway. Then, Dr. Lake claimed they were only trying to help him, to which Freeze replied quoting what she had said before his own procedure: "Remember there might be some momentary discomfort" and then blasted her with a freezing beam, trapping her in ice. She most likely died even before the building collapsed on top of her.