Born into a family of prominent businessmen in Gotham City, Victor Zsasz directed his life to amassing a large personal fortune in addition to his family's wealth. This all changed by putting him into a deep depression when his parents died in a boating accident at a young age, so he tried supporting himself through gambling, which instead lost him all his inherited fortune in every competition. Therefore, Zsasz saw his life as empty while growing up on the city streets, and was driven by desire of making a living in violence, bullying and terror, which many suggested was part of a seemingly unimpaired sense of morality. As a result, he turned to Gotham's organized crime, seeing it as a family he might fit in with when he found a father figure with in it's head mafia boss, Carmine Falcone. To earn Falcone's approval, Zsasz proved himself as an expert assassin among the crime lord's thugs and became one of Gotham's most wanted mob serial killers for each homicidal action he took.
Rachel Dawes stated that Zsasz murders people for the mob and is one of Carmine Falcone's many thugs. Dr. Jonathan Crane testified in Court that Zsasz was legally insane and should be transferred to Arkham Asylum for rehabilitation.
During both Ra's al Ghul and Scarecrow's reign of terror, Victor Zsasz was released from the asylum alongside the other crazed inmates. In the streets of Gotham, Zsasz almost attacked Rachel and a kid but was stopped by Batman.
It is revealed in one of the promotional websites that at the time of The Dark Knight he is still currently at large.
- This version of Victor Zsasz is the only one with brown hair and a goatee, the comics Zsasz only has blonde hair and no goatee.
- When Zsasz in his being released from his cell and turns his head, one of his trademark tally marks is exposed.
- In the movie, Zsasz has no dialogue and does not appear to be insane, unlike the comics version.
- A promotional website for The Dark Knight reveals that Zsasz is still at large. His fate by the events of The Dark Knight Rises is unknown but it seems certain that he is either incarcerated, still at large, or deceased.
- Zsasz also appears in the video game tie-in, with Tim Booth reprising the role.
- Zsasz's portrayal as a mob enforcer and hitman would later be carried over into his next two live-action appearances, first in the 2014 television series Gotham and then the 2020 film Birds of Prey. In Gotham he is shown to be a hitman for that incarnation of Carmine Falcone.